Home » Brain Function » Parkinsons » Parkinson’s disease 2016 update: risk higher with iron overload, new treatment target identified Parkinson’s disease 2016 update: risk of Parkinson’s disease is higher with iron overload, and a new treatment target has been identified.
Excess iron is commonly found in the brains of individuals with Parkinson’s disease, but it is not fully understood how excess iron damages neurons in Parkinson’s disease (PD). Researchers from the Andersen lab at the Buck Institute found that damage occurs from an impairment of lysosome, which is an organelle that acts as a cellular recycling center for damaged proteins. The researchers note that the impairment allows excess iron to escape into the neurons where it causes damaging oxidative stress.
Lysosomes play a key role in autophagy, a process in which damaged proteins are broken down and recycled so new ones can be built and take their place. With age, […]